Principal Scientist, In Vivo Pharmacology, Neurology

Description Principal Scientist, In Vivo Pharmacology, Neurology Remote U.S. or Palo Alto, CA About GondolaBio GondolaBio is a clinical-stage biopharmaceutical company focused on developing breakthrough therapeutics for genetic diseases. GondolaBio is an independent sister company to BridgeBio, originally carved out in 2024 after securing $300M in private financing from external investors. GondolaBio aims to leverage cutting-edge biological research to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases. Who You Are You are an experienced in vivo pharmacology scientist with expertise in Neurology. You have demonstrated success in developing and/or applying in vivo disease models to drug discovery campaigns. You have extensive hands-on experience with rodent Neurology model characterization, test article dosing, tissue processing, and common wet lab techniques (e.g. qPCR, Western blot, ELISA). You are execution-oriented, capable of driving work through CROs and external partners, and thrive in a fast-paced biotech environment. Key Responsibilities

• Design and execute on in vivo pharmacology studies across multiple Neurology programs in our research portfolio in rodents and non-human primates, with goals of IND submission.
• Partner with toxicology and translational teams to ensure our in vivo pharmacology data package is rigorous, reproducible, and translatable — directly informing dose selection and go/no-go decisions.
• Develop and implement pharmacodynamic and efficacy assessments, troubleshoot assays, and QC data from CROs and external partners.
• Manage CRO relationships and monitor study progress for ongoing studies, identifying emerging risks, while presenting progress updates in team meetings.
• Analyze data from in vivo pharmacology endpoints including PK/bioanalysis and pharmacodynamic and/or efficacy endpoints. Requirements Preferred Education & Experience
• Bachelor’s degree and 6+ years of biopharmaceutical industry experience within in vivo pharmacology.
• Experience with small molecules and antisense oligonucleotides (ASOs) is preferred.
• Experience in rare disease or developmental and epileptic encephalopathy (DEE) models is strongly preferred.
• Strong intellectual curiosity as demonstrated by routine engagement with scientific community and familiarity with literature.
• Direct experience and willingness to continue to design pharmacology studies with direct involvement and leading coordination of external efforts.
• Exposure to IND-enabling studies and experience writing regulatory or technical reports.
• Ability to operate independently and cross-functionally in a lean, fast-moving biotech environment. No matter your role at GondolaBio, successful team members are
• Patient Champions who put patients first, uphold strict ethical standards, and anchor decisions in clinical and scientific integrity.
• Entrepreneurial Operators who take ownership and drive toward practical solutions, while exercising sound judgment, respecting established processes, and aligning with teammates and leadership.
• Truth Seekers who are rigorous, detail-oriented, and intellectually honest—comfortable challenging assumptions, engaging with data, and updating their views based on evidence.
• Collaborative Thinkers who work effectively in data-driven, interdisciplinary environments; listen actively; and welcome questions, debate, and constructive challenge as essential to better decision-making.
• Individuals Who Inspire Excellence in themselves and those around them.
• High-quality Executors who deliver against goals and milestones with precision, accountability, and appropriate urgency—without compromising scientific rigor or team alignment. What We Offer
• Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts.
• A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak.
• An unyielding commitment to always putting patients first.
• A decentralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science.
• A place where you own the vision – both for your program and your own career path.
• A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game.
• Access to learning and development resources to help you get in the best professional shape of your life
• Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs).
• Flexible PTO.
• Rapid career advancement for strong performers.
• Potential ability to work on multiple GondolaBio Pharma programs across multiple therapeutic areas over time.
• Commitment to Diversity, Equity & Inclusion. The base pay range for this position is $173,000 to $205,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered. GondolaBio ServiceCo is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. Employees of BridgeBio and all affiliated companies should work through their managers to inquire about and learn more about this role.